Endian

Little Endian: Values are written with the least significat bit first followed by more significant bytes

Big Endian: The most significant byte is written first, followed by lesser significant bytes

Example with the value 300 (0x0000012c):

little endian: 0x2c 0x01 0x00 0x00

big endian: 0x00 0x00 0x01 0x2c

x86 uses the little endian way of notation, the only times you can encounter it on a computer is when using an emulator that doesn't the swap automatically (Some emulators do the conversion of big endian to little endian internally to speed up emulation)

Cheat Engine and Big Endian

Cheat engine does not current support big endian by default, but it is possible to write a custom scan script that converts the value to be checked to little endian before it is compared against user input

Another method that might be easier, would be to use 1 byte scan values only